Overall Madrid Andalusia MMR Concomitant
Incidence (CI95%) Incidence (CI95%) Incidence (CI95%) Incidence (CI95%)
Incidence of AEs by AC and co-vaccination with MMR
All AEs 4.67 (4.27-5.10) 4.75 (4.14-5.44) 4.61 (4.11-5.17) 4.73 (4.12-5.41)
ISR 2.83 (2.57-3.11) 2.69 (2.32-3.11) 2.94 (2.59-3.31) 2.68 (2.31-3.10)
Systemic Events 1.31 (1.18-1.45) 1.32 (1.12-1.54) 1.31 (1.14-1.49) 1.33 (1.13-1.56)
Solicited 3.52 (3.21-3.85) 3.78 (3.28-4.34) 3.35 (2.97-3.77) 3.76 (3.26-4.32)
Unsolicited 0.78 (0.70-0.88) 0.80 (0.67-0.95) 0.77 (0.66-0.90) 0.80 (0.67-0.96)
Incidence of SAEs by AC and co-vaccination MMR
All SAEs 0.005 (0.002-0.013) 0.009 (0.003-0.024) 0.003 (0.001-0.011) 0.009 (0.003-0.024)
ISR 0.002 (0.000-0.007) 0 0.003 (0.001-0.011) 0
Systemic Events 0.004 (0.001-0.01) 0.009 (0.003-0.024) 0 0
Solicited 0 0 0 0
Unsolicited 0.005 (0.002-0.013) 0.009 (0.003-0.024) 0.003 (0.001-0.011) 0.009 (0.003-0.024)
Incidence of ARs by AC and co-vaccination with MMR
SARs 0.004 (0.001-0.010) 0.004 (0.001-0.016) 0.003 (0.001-0.011) 0.004 (0.001-0.016)
ARs 3.13 (2.85-3.43) 3.30 (2.85-3.80) 3.02 (2.67-3.40) 3.28 (2.84-3.78)
ARs intensity
Mild 1.70 (1.53-1.88) 2.03 (1.74-2.36) 1.50 (1.31-1.72) 1.98 (1.69-2.31)
Moderate 0.54 (0.47-0.62) 0.44 (0.35-0.55) 0.62 (0.52-0.73) 0.45 (0.36-0.56)
Severe 0.31 (0.26-0.37) 0.29 (0.23-0.38) 0.33 (0.26-0.40) 0.30 (0.23-0.39)
ARs leading to a visit 0.03 (0.02-0.04) 0.01 (0.0-0.03) 0.03 (0.02-0.06) 0.03 (0.00-0.03)
ISR 2.83 (2.57-3.11) 2.69 (2.32-3.11) 2.94 (2.59-3.31) 2.68 (2.31-3.10)
Unsolicited 0.16 (0.13-0.20) 0.15 (0.11-0.21) 0.17 (0.13-0.22) 0.15 (0.10-0.21)
Solicited 2.69 (2.44-2.95) 2.69 (2.32-3.11) 2.68 (2.37-3.03) 2.68 (2.30-3.09)
Systemic Events 0.32 (0.27-0.37) 0.47 (0.38-0.59) 0.22 (0.18-0.28) 0.48 (0.38-0.59)
Unsolicited 0.03 (0.02-0.05) 0.04 (0.02-0.07) 0.02 (0.01-0.04) 0.04 (0.02-0.07)
Solicited 0.30 (0.25-0.35) 0.46 (0.36-0.57) 0.20 (0.16-0.26) 0.46 (0.36-0.57)
AEs Time of onset
Day0 18.39 (16.54-20.40) 17.55 (14.83-20.65) 18.98 (16.56-21.67) 17.50 (14.77-20.60)
Day0-Day7 8.70 (7.91-9.54) 8.99 (7.77-10.34) 8.50 (7.51-9.58) 8.95 (7.73-10.31)
Day8-Day30 0 0 0 0
Table 2: Incidence of adverse events, serious adverse events and adverse reactions (per person-month) by autonomous community and co-vaccination with MMR.