Total

Responder Group
(n=31)

Non-responder Group
(n=29)

p-valuea

IPSS total score

Baseline

16.1±9.2

22.4±7.4

11.0±5.0

<0.001

Endpoint

13.5±6.6

15.8±7.3

9.4±5.5

<0.001

p-valueb

<0.001

<0.001

<0.001

 

Endpoint-baseline

 

-6.6±2.9

-1.7±2.2

<0.001

IPSS irritative subscore

Baseline

8.0±5.1

11.0±5.0

6.1±2.5

<0.001

Endpoint

6.9±3.3

7.6±3.8

4.8±2.8

0.002

p-valueb

0.007

<0.001

<0.001

 

Endpoint-baseline

 

-3.4±2.2

-1.3±1.6

<0.001

IPSS obstructive subscore

Baseline

8.1±4.6

11.4±3.3

4.6±2.9

<0.001

Endpoint

6.6±3.8

8.2±4.3

4.9±2.4

0.001

p-valueb

<0.001

<0.001

0.245

 

Endpoint-baseline

 

-3.3±2.1

0.3±1.6

<0.001

Qmax (ml/sec)

Baseline

11.0±4.2

12.4±3.8

9.6±4.2

0.01

Endpoint

14.2±4.7

15.3±4.8

13.1±4.4

0.08

p-valueb

<0.001

0.003

<0.001

 

Endpoint-baseline

 

2.87±4.9

3.6±3.4

0.536

PVR (ml)

Baseline

30.6±35.6

32.1±27.9

28.6±43.0

0.391

Endpoint

24.2±28.2

22.7±23.2

28.4±34.1

0.509

p-valueb

0.034

0.004

0.556

 

Endpoint-baseline

 

-9.4±16.7

-3.0±27.4

0.286

IIEF-5

Baseline

8.3±8.1

7.2±7.6

9.4±8.5

0.456

Endpoint

7.6±8.3

7.4±8.1

8.0±8.7

0.342

p-valueb

0.231

0.842

0.02

 

Endpoint-baseline

 

0.2±4.5

-1.4±3.2

0.112

Table 2: