ED50 (µM)a

Selectivity

 

 

X

R

KB

KB-VIN

KB/KB-VIN

1

Desmosdumotin B

-

-

>135

6.8

>20

2

-

-

39.2

0.08

460

3

O

-

>61

5.2

>12

4

S

-

>58

8.7

>6.7

5

O

H

>61

7.9

>7.7

6

S

H

50.9

3.2

16

7

S

Me

37.7

27.4

1.4

8

-

-

51.6

15.6

3.3

9

-

-

>59.0

42.8

>1.4

10

-

-

>33

>33

1

11

-

-

30.8

8.3

3.7

NSC73306b

 

 

10.65 (KB-3-1)

1.47

7.3

Paclitaxel

 

 

0.007

1.77

0.004

aCytotoxicity as ED50 values for each cell line, the concentration of compound that caused 50% reduction in absorbance at 562 nm relative to untreated cells using the sulforhodamine B assay. Epidermoid carcinoma of the nasopharynx (KB), and MDR line overexpressing P-glycoprotein (KB-VIN).bThe data were cited from ref [10]

Table 1: Activity of 111against KB and KB-VIN