Table 1

				ED50 (µM)^a		Selectivity
		X	R	KB	KB-VIN	KB/KB-VIN
1	Desmosdumotin B	-	-	>135	6.8	>20
2		-	-	39.2	0.08	460
3		O	-	>61	5.2	>12
4		S	-	>58	8.7	>6.7
5		O	H	>61	7.9	>7.7
6		S	H	50.9	3.2	16
7		S	Me	37.7	27.4	1.4
8		-	-	51.6	15.6	3.3
9		-	-	>59.0	42.8	>1.4
10		-	-	>33	>33	1
11		-	-	30.8	8.3	3.7
NSC73306^b				10.65 (KB-3-1)	1.47	7.3
Paclitaxel				0.007	1.77	0.004

^aCytotoxicity as ED50 values for each cell line, the concentration of compound that caused 50% reduction in absorbance at 562 nm relative to untreated cells using the sulforhodamine B assay. Epidermoid carcinoma of the nasopharynx (KB), and MDR line overexpressing P-glycoprotein (KB-VIN).^bThe data were cited from ref [10]

Table 1: Activity of 1–11against KB and KB-VIN