Lipophilicity

s1 Receptor Binding Parameters

Compound

w

ClogP

IC50 (nM)

Ki (nM)

Hill Slope

 

 

 

 

 

 

4, 2-F; n = 4

ND

5.03

   17.48 ± 0.31

    12.08 ± 0.22

-1.07 ± 0.01

 

 

 

 

 

 

5, 3-F; n = 4

ND

5.03

   11.21 ± 1.29

      7.74 ± 0.89

-1.13 ± 0.09

 

 

 

 

 

 

6, 4-F; n = 4

2.54 ± 0.05

5.03

   11.34 ± 2.02

      7.83 ± 1.39

-1.21 ± 0.05

 

 

 

 

 

 

7, 2-Br; n = 3

3.09 ± 0.05

5.75

   26.62 ± 3.95

    18.39 ± 2.73

-0.78 ± 0.03

 

 

 

 

 

 

8, 3-Br; n = 3

3.06 ± 0.07

5.75

     9.14 ± 0.85

      6.35 ± 0.59

-1.02 ± 0.15

 

 

 

 

 

 

9, 4-Br; n = 3

3.31 ± 0.08

5.75

     9.85 ± 3.92

      6.80 ± 2.71

-1.00 ± 0.02

 

 

 

 

 

 

10, 2-I; n = 2

ND

6.01

   62.47 ± 0.96

    43.15 ± 0.66

-1.12 ± 0.03

 

 

 

 

 

 

11, 4-I; n = 4

3.71 ± 0.05

6.01

   22.89 ± 0.94

    15.82 ± 0.65

-1.59 ± 0.08*

 

 

 

 

 

 

ND = not determined. Binding parameters are means SEM for two to four assays, each performed in duplicate, n = number of trials. * Significantly different from unity.
Table 1: Lipophilicity measurements and σ1 receptor binding parameters.