Comd R R1 Rf Vlaue Yield (%) M.P(°C) AchEa IC50(µM)±SEM BuchEb IC50(µM)±SEM Selectivity for AChEc
3a Pyridyl- H 0.67 74 204 0.42±0.02 3.4±0.02 8.09
3b 4-flurophenyl- H 0.64 65 183 1.12±0.02 2.12±0.02 1.89
3c 3,4-Dimethoxy phenyl-- H 0.69 72 194 3.2±0.02 1.2±0.02 0.37
3d Phenyl- H 0.62 80 161 1.12±0.1 3.10±0.1 2.76
3e 2-Chloro phenyl- H 0.78 82 138 1.8±0.01 4.3±0.01 2.3
3f Pyridyl- Cl 0.73 85 113 0.37± 0.01 3.8± 0.01 10.20
3g 4-flurophenyl- Cl 0.76 92 126 1.6±0.1 3.7±0.1 2.3
3h 3,4-Dimethoxy phenyl-- Cl 0.74 85 105 2.2±0.1 4.2±0.1 1.90
3i Phenyl- Cl 0.66 77 154 3.2±0.1 11.2±0.1 3.50
3j 2-Chloro phenyl- Cl 0.70 82 162 2.6±0.1 6.6±0.1 2.50
3k Pyridyl- NO2 0.78 90 126 0.10±0.1 4.10±0.1 36.41
3l 4-flurophenyl- NO2 0.82 56 178 8.6±0.1 1.6±0.1 0.18
3m 3,4-Dimethoxy phenyl- NO2 0.85 81 194 6.10±0.1 3.10±0.1 0.50
3n Phenyl- NO2 0.59 76 172 13.2±0.1 2.2±0.1 0.16
3o 2-Chloro phenyl- NO2 0.83 72 182 7.6±0.1 1.6±0.1 0.20
Drug Donepezil.HCl - - - - 0.12±0.01 3.6±0.1 30.0
Table 1: Physical constants and Inhibition of AchE and BuchE activities of the synthesized compounds.