Preparation Method

Entrapment efficiency
(mean±SEM)

Amount of folate on
the surface of nanoparticles
(µM of folic acid/gm of nanoparticles)

O/W emulsion solvent evaporation method

51.9±2.1

4.08±0.9

W/O/W double emulsion solvent evaporation method

24.5±1.4

3.57± 0.5

Dialysis method

32.6±2.4

7.0±1.6

S.E.M: Standard error of Mean
Table 2: Entrapment efficiency and folate content of nanoparticles prepared by various methods using PLGA-PEG-FOL polymer.