Water GFJ p-value
mean ±SD mean ±SD
Active HMG-CoA reductase inhibitors
Cmax (ng/mL) 1.94 ±0.69 2.73 ±1.10 NS
Tmax (hr) 2.3 ±0.1 3.6 ±1.8 NS
AUC (0-8hr) 8.7 ±3.7 14.5 ±6.3 0.024
Active HMG-CoA reductase inhibitors
Cmax (ng/mL) 7.11 ±3.17 8.54 ±2.89 NS
Tmax (hr) 1.5 ±0.5 1.8 ±0.9 NS
AUC (0-8hr) 22.9 6.7 38.2 ±11.2 0.002
Table 1: Pharmacokinetic parameters of active HMG-CoA reductase inhibitors and total HMG-CoA reductase inhibitors.