Simvastatin/ Grapefruit juice/ day Cmax AUC
W/G-Active W/G-Total W/G-Active W/G-Total
  ng/ml (p) ng/ml (p)  
60mg/1200ml (3) 3.1/ 20.3 15.6/ 147.0 21.7/ 147.0 46.6/ 752
(p<0.001) ( p <0.01) (p<0.05)
40mg/1200ml (4) 3.9/ 19.6 9.3/ 112.0 24.9/ 114.0 27.8/ 373.0
(p<0.001) (p<0.001)
40mg/200ml (5) 2.6/ 11.1 7.3/ 28.5 18.5/ 62.0 31.6/ 112.5
(p<0.001) (p<0.001)
W: water group, G: grapefruit juice group, Active: concentration of active
simvastatin acid, Total: concentration of total simvastatin
Active Inhibitors*: Active HMG-CoA reductase inhibitors
Total Inhibitors*: Total HMG-CoA reductase inhibitors
Ng-eq/ml** refers to the nanogram equivalents of simvastatin acid
Table 2: Review of the literature measuring active and total simvastatin level with regard to interaction of grapefruit juice with simvastatin.