Simvastatin/ Grapefruit juice/day Cmax AUC W/G-Active W/G-Total W/G-Active W/G-Total Inhibitors* Inhibitors* ng-eq/ml** (p) ng-eq/ml **(p) 60mg/1200m (3) 21.0/ 26.8 86.7/ 159 88.0/ 213 243/ 862 ( p<0.05) (p<0.01) ( p<0.01 ) 5mg/ 400ml (present series) 1.9/ 2.7 7.1/ 8.5 8.7/ 14.5 22.9/ 38.2   ( NS ) (p=0.024) (p=0.002)

W: water group, G: grapefruit juice group, Active Inhibitors*: active HMG-CoA reductase inhibitors, Total Inhibitors*: total HMG-CoA reductase inhibitors Ng-eq/ml** refers to the nanogram equivalents of simvastatin acid

Table 3: Review of the literature measuring HMG-CoA reductase inhibitors level with regard to interaction of grapefruit juice with simvastatin.