Simvastatin/ Grapefruit juice/day Cmax AUC
W/G-Active W/G-Total W/G-Active W/G-Total
Inhibitors* Inhibitors*
ng-eq/ml** (p) ng-eq/ml **(p)
60mg/1200m (3) 21.0/ 26.8 86.7/ 159 88.0/ 213 243/ 862
( p<0.05) (p<0.01) ( p<0.01 )
5mg/ 400ml (present series) 1.9/ 2.7 7.1/ 8.5 8.7/ 14.5 22.9/ 38.2
  ( NS ) (p=0.024) (p=0.002)
W: water group, G: grapefruit juice group, Active Inhibitors*: active HMG-CoA
reductase inhibitors, Total Inhibitors*: total HMG-CoA reductase inhibitors
Ng-eq/ml** refers to the nanogram equivalents of simvastatin acid
Table 3: Review of the literature measuring HMG-CoA reductase inhibitors level
with regard to interaction of grapefruit juice with simvastatin.