Group Conc.(µM) Inhibition rate (%) on HDAC( ± SD, n=3)
CI-994 Z-GP-CI-994
1.0 48.72 ± 3.79 14.02 ± 2.26*
2.0 56.65 ± 5.63 28.97 ± 6.34*
3.0 61.44 ± 1.09 22.55 ± 9.66*
4.0 68.53 ± 2.74 31.13 ± 4.46*
5.0 78.04 ± 3.35 37.43 ± 3.52*
t-test vs CI-994: * P < 0.01
Table 1: The inhibitory effects of CI-994 and Z-GP-CI-994 on HDAC.