compounds Immobility time(seconds)
Control 183 ± 5.3
DMSO 160 ± 10.2
IVa 78 ± 2.9 *
VIb 71.4 ± 5.4 *
IVc 80 ± 5.7 *
VIc 57.8 ± 4.9 *
IVd 51.8 ± 3.2 *
clozapine 121 ± 6.6 *
Table 2: Evaluation of C.N.S. depressant activity of compounds and clozapine (3 mg/kg, i.p.) on mice using the forced swim test.