(A). 4a (JBIR-94) binds vicinity of Leu188, Ala561, Asn187, Ser562 amino acid residues of 5-LOX crystal protein with binding energy of −138.67 kcal/mol. (B). 4h binds in the vicinity of Leu188, Asp368, Ser562, Asn187 amino acid residues of 5-LOX crystal protein with binding energy of −141.23 kcal/mol.
Figure 1: Molecular docking studies and interaction analysis of 4a and 4h on 5-Lipoxygenase enzyme crystal sructure (PDB ID 308Y).