S. No Entry R 6Yield (%)a
1 6a Ph 92
2 6b 4-Me Ph 92
3 6c 3-OMe Ph 90
4 6d 3,4-diOMe Ph 90
5 6e 4-F Ph 86
6 6f 2-I Ph 88
7 6g 2,4-diCl Ph 86
8 6h Me 94
9 6i Et 94
10 6j Pentyl 92
aIsolated yields
Table 2: Synthesis of N1,N6-phenyl and N1,N6-alkyl putrescine bisamides.