Entry 5-LOX inhibitory activity (Anti-inflammatory activity) Antioxidant activity (Radical scavenging activity)
In vitro studies IC50 (μg/ml) Insilico studies Dock score (Kcal/mol) DPPH Superoxide IC50 (μg/ml)
4a 9.7 -138.67 10.99 9.8
4b ND -110.76 8.3 7.8
4c 13.1 -129.32 8.5 7.6
4d 13.3 -128.21 8.8 7.5
4e 14.1 -124.87 10.0 9.1
4f 15.4 -119.67 9.5 9.8
4g 15.3 -118.56 15.4 19.8
4h 9.2 -141.23 5.6 7.6
4i 12.2 -122.65 13.1 14.2
6a 14.6 -126.61 14.2 14.3
6b 13.4 -121.01 10.0 13.1
6c 13.5 -127.21 9.3 10.3
6d 14.4 -129.34 12.2 10.9
6e 10.4 -118.32 15.5 13.03
6f 10.1 -108.49 16.43 15.02
6g 10.1 -119.94 14.45 13.5
6h 21.0 -102.56 8.7 10.3
6i 26.5 -99.23 10.2 11.2
6j 29.2 -98.92 11.2 11.9
Standard* 4.40 -154.92 3.6 3.3
* Nordihydroguaiaretic acid for 5-LOX, Ascorbic acid for antioxidant activity, ND; Not Determined.
Table 4: Anti-inflammatory and antioxidant activities of newly synthesized putrescine bisamides.