Compd. R IC50a (μL)
    PLC U266 HEPG-2 HCT116 ES-2
XGS-1 Methyl ≥200 ± 1.12 99.69 ± 2.31 135.93 ± 1.55 ≥200 ≥200
XGS-2 Ethyl ≥200 ± 0.87 ≥200 ≥200 ≥200 ≥200
XGS-3 n-Propyl 193.38 ± 0.65 48.92 ± 0.97 ≥200 ≥200 130.832 ± 0.89
XGS-4 sec-Propyl 200 ±  0.32 85.97 ± 0.46 82.12 ± 1.78 ≥200 166.844 ± 5.19
XGS-5 1-Chloro-methyl 74.54 ±  0.73 7.57 ± 0.21 29.72 ± 0.34 122.24 ± 0.63 148.49 ± 1.98
XGS-6 3-Nitrophenyl 93.21 ± 1.32 103.29 ± 0.79 97.29 ± 0.58 151.31 ± 0.076 164.504 ± 0.93
XGS-7 3,4,5-Trimethyphenyl 178.34 ± 0.56 39.861 ± 0.96 145.16 ± 0.69 130.47 ± 1.39 124.351 ± 1.21
XGS-8 p-Acetamidophenyl 176.43 ± 0.78 31.01 ± 0.64 55.65 ± 0.77 ≥200 161.167 ± 0.33
XGS-9 4-Fluorophenyl ≥200 29.49 ± 0.57 177.46 ± 1.61 125.47 ± 1.99 150.92 ± 1.97
XGS-10 4-Nitrophenyl ≥200 48.32 ± 2.15 ≥200 ≥200 ≥200
XGS-11 Phenyl 96.93 ± 2.16 69.18 ± 1.57 119.56 ± 0.64 ≥200 150.923 ± 3.21
XGS-12 4-Methoxyphenyl 163.03 ± 0.67 1.75 ± 0.055 0.68 ± 0.0032 153.67 ± 3.16 98.524 ± 1.34
XGS-13 4-Bromo-2-fluorophenyl 126.47 ± 2.89 26.27 ± 3.42 54.82 ± 0.87 114.25 ± 0.78 117.557 ± 0.56
XGS-14 2-Naphthyl 113.62 ± 1.23 2.71 ± 0.032 0.75 ± 0.045 ≥200 121.535 ± 0.64
XGS-15 4-(1,1'-Biphenyl) 52.89 ± 1.54 1.24 ± 0.21 0.78 ± 0.097 65.75 ± 0.28 31.24 ± 1.69
Pazopanib ≥200 3.25 ± 0.12 118.47 ± 0.67 181.82 ± 1.89 ≥200
Data represent the mean ± SD of two experiments.
Table 1: Antiproliferative activities of compounds XGS-1 to XGS-15 and Pazopanib against five tumor cell lines.