Figure 2: Synthetic scheme to prepare the hybrid compounds.
a.Sodiumethoxide/DMF/95-100 0C or Sodium carbonate/95% ethanol/85 0C for intermediates 1 and 6, respectively.
b. SnCl2 /CH3COOH/ HCl//9500C
c. Chloracetylchloride/CH3COOH
d. Homoveratrylamine for 4&9, or N-methylhomoveratrylamine for 5 &10/ benzene/reflux