Compound ED50 (µmol/kg)
  Leukocyte migration TNF-α production
ASA 128.0* N.R.
imatinib 5.0* 0.44*
2c (LASSBio-1597) 5.1* 4.4*
6 (LASSBio-1724) 5.35* 9.26*
7 (LASSBio-1725) 6.1* 8.8*
8 (LASSBio-1726) 3.2* 8.6*
9 (LASSBio-1723) 4.45* 0.07*
10 (LASSBio-1727) 5.4* 0.9*
-N.R. not realized; ASA = acetylsalicylic acid. N=7-10 per group. Doses: 1-50 (µmol/kg). Statistical significance between groups was calculated using analysis of variance (ANOVA) followed by Bonferroni test. P values less than 0.05 (*p < 0.05) were used as significant level.
Table 3: Effects of carboxamides 2c, 6-10, imatinib and acetylsalicylic acid (ASA) in leukocyte migration and TNF-α production induced by carrageenan injection into the subcutaneous air pouch.