Time pH 1 pH 4 pH 7.4 pH 9
(mins) Prazosin and amlodipine (available %)
  PRZ AML PRZ AML PRZ AML PRZ AML
0 99.89 98.78 99.59 99.48 100.15 100.28 100.29 98.48
30 92.19 93.72 100.19 99.12 105.00 102.93 104.58 97.74
60 93.75 95.30 107.24 106.57 104.90 104.97 100.77 101.99
90 98.67 100.34 110.08 109.81 79.35 107.29 110.85 111.23
120 108.21 110.79 114.40 110.73 62.70 112.19 118.26 119.53
150 114.94 116.23 116.43 110.40 63.61 120.26 121.90 119.07
180 119.59 122.08 119.40 117.34 55.44 127.20 131.78 130.38
Prazosin and Diltiazem (available %)
  PRZ DIL PRZ DIL PRZ DIL PRZ DIL
0 101.21 100.85 100.10 99.98 100.12 100.25 100.28 100.59
30 104.26 105.04 101.59 100.38 104.55 104.09 101.12 101.79
60 107.37 107.07 101.97 101.58 77.84 106.42 100.43 98.47
90 108.84 108.91 100.70 101.79 79.79 106.38 111.24 113.06
120 109.99 109.94 101.51 102.33 48.75 106.33 117.43 124.39
150 114.86 115.81 110.14 109.98 52.74 106.41 119.63 123.68
180 116.93 117.08 110.68 110.76 61.24 117.30 133.12 141.07
Prazosin and Verapamil (available %)
  PRZ VER PRZ VER PRZ VER PRZ VER
0 100.54 101.12 99.89 100.21 99.87 99.78 100.01 100.12
30 122.85 115.74 99.99 101.01 98.54 99.42 102.57 102.72
60 120.98 112.95 102.25 103.09 96.63 101.47 108.06 105.06
90 129.20 120.11 102.67 103.74 77.00 102.85 115.62 115.91
120 139.38 131.47 107.34 109.61 61.78 107.80 117.44 117.14
150 145.90 134.07 107.61 108.47 61.06 109.65 130.29 131.88
180 158.10 150.22 108.61 111.03 50.86 117.27 142.63 143.29
Table 7: Interaction studies between prazosin and calcium channel blockers at 37°C