| Time |
pH 1 |
pH 4 |
pH 7.4 |
pH 9 |
| (mins) |
Prazosin and amlodipine (available %) |
| |
PRZ |
AML |
PRZ |
AML |
PRZ |
AML |
PRZ |
AML |
| 0 |
99.89 |
98.78 |
99.59 |
99.48 |
100.15 |
100.28 |
100.29 |
98.48 |
| 30 |
92.19 |
93.72 |
100.19 |
99.12 |
105.00 |
102.93 |
104.58 |
97.74 |
| 60 |
93.75 |
95.30 |
107.24 |
106.57 |
104.90 |
104.97 |
100.77 |
101.99 |
| 90 |
98.67 |
100.34 |
110.08 |
109.81 |
79.35 |
107.29 |
110.85 |
111.23 |
| 120 |
108.21 |
110.79 |
114.40 |
110.73 |
62.70 |
112.19 |
118.26 |
119.53 |
| 150 |
114.94 |
116.23 |
116.43 |
110.40 |
63.61 |
120.26 |
121.90 |
119.07 |
| 180 |
119.59 |
122.08 |
119.40 |
117.34 |
55.44 |
127.20 |
131.78 |
130.38 |
| Prazosin and Diltiazem (available %) |
| |
PRZ |
DIL |
PRZ |
DIL |
PRZ |
DIL |
PRZ |
DIL |
| 0 |
101.21 |
100.85 |
100.10 |
99.98 |
100.12 |
100.25 |
100.28 |
100.59 |
| 30 |
104.26 |
105.04 |
101.59 |
100.38 |
104.55 |
104.09 |
101.12 |
101.79 |
| 60 |
107.37 |
107.07 |
101.97 |
101.58 |
77.84 |
106.42 |
100.43 |
98.47 |
| 90 |
108.84 |
108.91 |
100.70 |
101.79 |
79.79 |
106.38 |
111.24 |
113.06 |
| 120 |
109.99 |
109.94 |
101.51 |
102.33 |
48.75 |
106.33 |
117.43 |
124.39 |
| 150 |
114.86 |
115.81 |
110.14 |
109.98 |
52.74 |
106.41 |
119.63 |
123.68 |
| 180 |
116.93 |
117.08 |
110.68 |
110.76 |
61.24 |
117.30 |
133.12 |
141.07 |
| Prazosin and Verapamil (available %) |
| |
PRZ |
VER |
PRZ |
VER |
PRZ |
VER |
PRZ |
VER |
| 0 |
100.54 |
101.12 |
99.89 |
100.21 |
99.87 |
99.78 |
100.01 |
100.12 |
| 30 |
122.85 |
115.74 |
99.99 |
101.01 |
98.54 |
99.42 |
102.57 |
102.72 |
| 60 |
120.98 |
112.95 |
102.25 |
103.09 |
96.63 |
101.47 |
108.06 |
105.06 |
| 90 |
129.20 |
120.11 |
102.67 |
103.74 |
77.00 |
102.85 |
115.62 |
115.91 |
| 120 |
139.38 |
131.47 |
107.34 |
109.61 |
61.78 |
107.80 |
117.44 |
117.14 |
| 150 |
145.90 |
134.07 |
107.61 |
108.47 |
61.06 |
109.65 |
130.29 |
131.88 |
| 180 |
158.10 |
150.22 |
108.61 |
111.03 |
50.86 |
117.27 |
142.63 |
143.29 |
|