Compound nOH NSR IC50(1)/IC50(i) ln[IC50(1)/IC50(i)] Ref.
1 3.17 4.00 1.00 0.00 35
2 4.00 4.50 7.40 2.00 35
3 3.83 4.66 2.28 0.82 35
4 3.83 4.66 1.78 0.58 35
5 1.67 4.33 0.08 −2.53 35
6 3.00 5.00 0.20 −1.61 36
7 3.30 4.30 1.08; 0.75 * 0.08; −0.29 36
8 3.00 6.00 0.14 −1.97 36
9 0.50 1.00 0.00; 0.00 * 36
10 2.83 4.50 0.09 −2.41 37
11 3.50 4.00 2.20; 1.80; 1.40 * 0.79; 0.59; 0.34 37
12 2.50 3.00 0.016 −4.13 37
13 2.50 3.00 0.016 −4.13 37
Table 2: Comparison of the antimalarial activity of compound 1 and its analogs (2−13) (35-37) with the number of hydroxyl radicals nOH, which are formed due to their intramolecular oxidation (28-31).