Entry COMP R X Zone of inhibition (mm)
50 ┬ÁL for well
1Anti-bacterial activity 2Anti-fungal activity
S.a B.s E.c P.a A.n P.r
1 7a H O 12 14 10 09 07 05
2 7b *Cl O 16 18 13 12 09 12
3 7c *Br O 18 16 15 11 14 10
4 7d *NO2 O 15 13 10 16 13 12
5 7e H NCH3 11 07 09 10 04 06
6 7f *Cl NCH3 17 12 15 18 11 13
7 7g *Br NCH3 19 16 12 14 09 08
8 7h *NO2 NCH3 17 13 11 14 12 14
Std Streptomycin 25 20 20 23 - -
Std Fluconazole - - - - 18 15
1S.a - Staphylococcus aureus, B.s - Bacillus subtilis, E.c - Escherichia coli,
P.a - Pseudomonas aeruginosa
2A.n - Aspergillus niger P.r - Penicillium rubrum
*Indicates more activity
Table 1: Anti-bcterial and anti-fungal activity of 3-chloro-4-(1-(morpholinomethyl) / ((4- methylpiperazin-1-yl) methyl)-1H-imidazol-4-yl)-1-(4-substituted phenyl) azetidin-2-one 7(a-h).