Compound Trypanocidal activity (%)a  
Epimastigote Trypomastigote Amastigote
10 μM 100 μM 10 μM 100 μM 10 μM 100 μM
2 NA 10 ± 1 12 ± 1 34 ± 1 - -
3 NA 11 ± 1 27 ± 1 37 ± 2 - -
4 12 ± 1 29 ± 2 11 ± 1 53 ± 4 - -
5 15 ± 1 78 ± 6 71 ± 6 96 ± 6 73 ± 7 100 ± 4
Nifurtimox 52 ± 2 100 ± 3 36 ± 3 100 ± 2 45 ± 3 100 ± 3
Values (mean ± SD) were obtained from three independent experiments.
NA inactive at concentration tested.
aResults are reported as the percentage of non-viable parasites regarding the control at 10 and 100 μM.
- Not tested
Table 1: Trypanocidal activity in different parasite stages for compounds 2-5 and the reference compound Nifurtimox at two different concentrations.