Parasite stage IC50 (μM)
Nifurtimox Compound 5
Epimastigote 17.4 ± 5.1 46.8 ± 3.7
Trypomastigote 10.0 ± 0.4 2.6 ± 0.2
Amastigote 18.6 ± 2.6 2.9 ± 0.1
The results are the means of three different experiments with a SD less than 10% in all cases.
aIC50: concentration that produces 50% of inhibitory effect.
Table 2: IC50 values for compound 5 and Nifurtimox in different parasite stages.