| |
|
Proliferation inhibition (%) |
| Compound |
c-Srckinase Inhibition
IC50 (µM)a |
HT-29 |
SK-OV-3 |
MCF-7 |
| b1 |
NDb |
<30 |
<30 |
NA |
| b2 |
41.4 |
<30 |
<30 |
NA |
| b3 |
ND |
50.0 |
NA |
60 |
| b4 |
ND |
<30 |
<30 |
NA |
| b5 |
40.5 |
41.0 |
<30 |
<30 |
| b6 |
ND |
NAc |
<30 |
NA |
| b7 |
ND |
<30 |
NA |
NA |
| b8 |
ND |
40 |
<30 |
NA |
| b9 |
ND |
NA |
<30 |
<30 |
| b10 |
36.5 |
NA |
<30 |
NA |
| b11 |
5.3 |
ND |
ND |
ND |
| b12 |
148.4 |
<30 |
NA |
<30 |
| b13 |
29.9 |
32 |
<30 |
47.0 |
| b14 |
ND |
<30 |
NA |
<30 |
| b15 |
50.8 |
82.0 |
68 |
<70 |
| b16 |
10.4 |
<30 |
NA |
<30 |
| b17 |
ND |
NA |
NA |
<30 |
| b18 |
23.9 |
NA |
<30 |
NA |
| b19 |
ND |
<30 |
<30 |
58.0 |
| b20 |
211.8 |
<30 |
NA |
<30 |
| b21 |
ND |
<30 |
NA |
<30 |
| b22 |
ND |
<30 |
NA |
<30 |
| b23 |
61.1 |
<30 |
NA |
<30 |
| b24 |
27.7 |
<30 |
NA |
<30 |
| b25 |
ND |
<30 |
<30 |
NA |
| b26 |
17.0 |
77.0 |
NA |
48.0 |
| b27 |
27.7 |
<30 |
<30 |
NA |
aThe concentration that inhibited enzyme activity by 50%;
bNotdetermined;cNoactivity. All data are average of triplicate experiments. |
|
