Authors Years Type of study Direct cost Indirect cost Total cost Average cost
Finnell et al 2009 A decision model
LTBI
Cost of driving:$5
Cost of INH: US $1/month
Cost of RMP:US $ 37/month
Cost of visit: US $28/month
Cost of treating reactivated TB: US$10 871
lost of parental work US $23   Medication,
administration
treatment of liver failure, TB reactivation
RMP: US $1 173
INH: US $ 1 235
INH+RMP: US $ 1 364
No treatment: US $1 413
Kellerman et al. 1994-1995 retrospective,
cost-effective analysis
TB control program
    Total cost of TB Control: US $15 270-28 158  
Pathania et al. 1995-1996 observational
cost-benefit analysis
BCG revaccination
n=134 233
Revaccination: KCR15 million/year
Benefit: KCR 13.7 million
Benefit : KCR16.56 million Total cost of inpatient care: KCR 36 244/case
Total cost of outpatient- care: KCR 10 644/case
 
Rahman et al. 1996 hypothetical cohort
cost-benefit
cost-effectiveness analysis
BCG revaccination
n=2.86 million
Prevention: US $108 378/case
TB treatment: US$ 11 576/case
Maximum benefit: US $ 23.6 million
  Total cost of revaccination: US $ 32.1 million  
Rahman et al. 1996 hypothetical cohort
cost-effectiveness analysis
BCG universal vaccination
n=1.2 million
Cost of prevention: US$35 950-175 862
Cost of side effects: US$ 1.18 million
  Total cost of vaccination:
US$19.5 million
 
Gounder et al. 1991-1995
1996-1998
follow up
cost-benefit analysis
school-based TB screening (TST)
n=788 283
Cost of outpatient TB treatment: US$ 1400-8000/case
Cost of hospitalization: US$ 18 588/case
  Total cost of TST: US$3 623 550
Total cost of dg workup: US$ 443 800
Total cost of INH prophylaxis: US$1 597 680
∑ US$5 665 030
 
Brassard et al. 1998-2003 retrospective
cost-benefit analysis
immigrant school-based TB screening (TST)
n=2524
    Total cost of screening: C$193 461
Total cost of treatment of prevented cases: C$557 384
Total savings of school-screening: C$363 923
 
Flaherman et al. 2007 cost-effectiveness analysis
decision tree model
kindergarten-TB screening
Estimated cost of TST: US$ 14.29/case
Cost of RQ: US$ 1.41/case
  Total cost of targeted TST: US$524 897
Total cost of universal TST: US$ 671 398
Total cost of no screening: US$ 0
Total saving with TT: US$ 1.27 million/year
 
Diel et al. 2004 cost-analysis
diagnostics and treatment of TB
Outpatient care with medication:€ 828.24 for culturally positive
Culturally negative: €699.94
Nurses’ salary: €323.06
     
Garg 2005 prospective study
chronic diarrhea in children
abdominal TB
n=3/50
charge of outpatient consultation: US $ 0.25     Average cost:
cost of consultation, stool microscopic examination, medicines: US $ 10
Jha et al. 1994 cost-analysis
cost-effectiveness analysis of forty health interventions in Guinea
n= -
Cost of salary: 16% of total in centre, 23% of total in hospital
Cost of drugs:73% of total in centre,23% of total in hospital
Cost of overheads:11% of total in centre, 54% of total in hospital
  Cost of short-course treatment in Centre: US$ 60/case
Cost of short-course treatment in hospital:US$234/case
 
dg-diagnosis, INH-isoniazid, KCR-Czech Koruna
MDR- multidrug-resistant, RMP-rifampin
RQ-risk factor questionnaire, TB-tuberculosis
TST-tuberculin skin test, TT-targeted tuberculin skin test
Table 3: Selected TB cost and cost-effectiveness studies