Figure 2: Analyzing human-MTB interacting protein functional similarity scores: Predicted human-MTB functional interactions lead to significantly higher functional similarity scores compared to random human-MTB interactions. The estimated distribution of random human-MTB interacting protein functional average similarity scores is used to determine whether the predicted human-MTB interacting protein functional similarity average score (μ=0.31) is significantly high. The red line indicates the approximate probability density function of the distribution of random human-MTB interacting protein average functional similarity scores, estimated using a Gaussian smoothing kernel.