Cluster Proteins Enriched Terms GO Ids GO term Level p-value Bonferonni-correction 1 216 2 GO:0006351 transcription, DNA-dependent 8 2.18796×10−10 2.88811×10−08       GO:0006355 regulation of transcription,DNA-dependent 8 1.59921×10−06 0.00021 2 120 5 GO:0006355 regulation of transcription,DNA-dependent 8 1.84432×10−08 3.68863×10−06       GO:0000160 phosphorelay signal transductionsystem 5 1.9038×10−07 3.80761×10−05       GO:0035556 intracellular signal transduction 5 3.52753×10−07 7.05507×10−05       GO:0006351 transcription, DNA-dependent 8 3.00490×10−06 0.00060       GO:0051409 response to nitrosative stress 3 0.00016 0.03255 3 64 4 GO:0040007 growth 1 2.01816×10−12 2.56307×10−10       GO:0044119 growth of symbiont in host cell 7 2.50787×10−06 0.00032       GO:0009097 isoleucine biosynthetic process 10 5.40389×10−05 0.00686       GO:0045893 positive regulation of transcription,DNA-dependent 9 0.00039 0.04926

Table 3: Clustering MTB annotated target proteins that showed no evidence to interact with human proteins. Different clusters identified and associated statistically relevant GO biological process terms associated with the gene list in each cluster.