Figure 1: The contribution of PZA to RIF- and RPT- containing regimens in M. tuberculosis-infected BALB/c and nude mice. (A) Mean log10 CFU counts in the lungs of mice receiving RIF+EMB with or without PZA. (B) Mean log10 CFU counts in the lungs of mice receiving RPT+EMB with or without PZA. Treatment was initiated on Day 0 (14 days after infection), and mice were treated 5 days per week at the following doses: RIF (R), 10 mg/kg; EMB (E), 100 mg/kg; PZA (Z), 150 mg/kg; RPT (P), 10 mg/kg. Error bars represent standard deviation. UT, untreated