| |
No. of mice to be sacrificed at the following time points |
| Day -13 |
Day 0 |
Wk 1 |
Wk 2 |
Wk 4 |
Wk 8 |
Wk 16 |
Total |
| Control Regimens |
| Untreated |
10 |
10 |
5 |
5 |
5 |
5 |
5 |
45 |
| RIF |
|
|
5 |
5 |
5 |
5 |
5 |
25 |
| INH |
|
|
5 |
5 |
5 |
5 |
5 |
25 |
| PZA |
|
|
5 |
5 |
5 |
5 |
5 |
25 |
| RIF+INH |
|
|
5 |
5 |
5 |
5 |
5 |
25 |
| Test Regimens |
| RIF+PZA |
|
|
5 |
5 |
5 |
5 |
5 |
25 |
| INH+PZA |
|
|
5 |
5 |
5 |
5 |
5 |
25 |
| RIF+INH+PZA |
|
|
5 |
5 |
5 |
5 |
5 |
25 |
| Total Mice |
10 |
10 |
40 |
40 |
40 |
40 |
40 |
220 |
Treatment was initiated two weeks after infection at Day 0 and was administered
for 16 weeks. |
