| |
Mean (SD) log10 M. bovis CFU counts in mouse lungs at the following time points |
| Day -13 |
Day 0 |
Wk 1 |
Wk 2 |
Wk 4 |
Wk 8 |
Wk 16 |
| Control Regimens |
| Untreated |
3.73 (0.13) |
6.56 (0.12) |
7.67 (0.17) |
8.69 (0.71) |
8.11 (0.33) |
8.79 (0.49)* |
|
| RIF |
|
|
7.15 (0.30) |
6.87 (0.29) |
6.75 (0.08) |
6.09 (0.16) |
5.79 (0.26) |
| INH |
|
|
6.46 (0.11) |
6.31 (0.22) |
5.70 (0.16) |
4.69 (0.31) |
3.86 (0.20) |
| PZA |
|
|
7.75 (0.21) |
8.17 (0.17) |
8.31 (0.62) |
7.5** |
|
| RIF+INH |
|
|
5.71 (0.19) |
5.03 (0.05) |
4.40 (0.18) |
2.72 (0.14) |
0 |
| Test Regimens |
| RIF+PZA |
|
|
7.04 (0.19) |
7.27 (0.51) |
6.96 (0.08) |
5.94 (0.23) |
5.82 (0.19) |
| INH+PZA |
|
|
6.99 (0.52) |
6.38 (0.36) |
5.80 (0.23) |
5.19 (0.36) |
4.12 (0.74) |
| RIF+INH+PZA |
|
|
5.47 (0.24) |
5.09 (0.28) |
4.39 (0.14) |
2.63 (0.23) |
0.68 (1.20) |
Treatment was initiated two weeks after infection at Day 0 and was administered
for 16 weeks. Drugs were administered 5 days per week at the following doses:
RIF, 10 mg/kg; INH, 10 mg/kg; PZA, 150 mg/kg.
*CFU counts from two surviving mice.
**CFU counts from a single mouse that survived to this time point. |
