| |
No. of mice to be sacrificed at the following time points |
|
| Day -13 |
Day 0 |
Wk 2 |
Wk 4 |
Wk 6 |
Wk 8 |
Total |
| Control Regimens |
|
| Untreated |
5 |
5 |
5 |
|
|
|
15 |
| RIF+INH+PZA+EMB |
|
|
5 |
5 |
5 |
5 |
20 |
| RIF+EMB |
|
|
5 |
5 |
5 |
5 |
20 |
| Test Regimen |
|
|
|
|
|
|
|
| RIF+EMB+PZA |
|
|
5 |
5 |
5 |
5 |
20 |
| Total Mice |
5 |
5 |
20 |
15 |
15 |
15 |
75 |
Treatment was initiated two weeks after infection at Day 0 and was administered
for 8 weeks. Ethambutol was included to prevent the emergence of drug resistance
in the nude mice. The same scheme was used for 75 BALB/c and 75 nude mice |
