| |
Mouse strain |
Mean (SD) log10 CFU counts in mouse lungs at the following time points |
| Day -13 |
Day 0 |
Wk 2 |
Wk 4 |
Wk 6 |
Wk 8 |
| Control Regimens |
| Untreated |
BALB/c |
3.80 (0.11) |
8.01 (0.05) |
|
|
|
|
| |
Nude |
3.90 (0.14) |
8.61 (0.44) |
|
|
|
|
| RIF+EMB+PZA+INH |
BALB/c |
|
|
5.73 (0.30) |
5.22 (0.06) |
4.10 (0.19) |
3.09 (0.14) |
| |
Nude |
|
|
6.19 (0.13) |
6.37 (0.41) |
4.71 (0.39) |
3.84 (0.17) |
| RIF+EMB |
BALB/c |
|
|
6.08 (0.13) |
5.69 (0.03) |
5.46 (0.17) |
4.65 (0.31) |
| |
Nude |
|
|
8.61 (0.31) |
6.21 (0.32) |
6.17 (0.27) |
5.29 (0.97) |
| Test Regimen |
| RIF+EMB+PZA |
BALB/c |
|
|
5.38 (0.23) |
4.55 (0.18) |
3.72 (0.19) |
2.55 (0.29) |
| |
Nude |
|
|
8.57 (0.59) |
7.03 (0.48) |
6.14 (0.34) |
6.21 (0.20) |
Treatment was initiated two weeks after infection at Day 0 and was administered
for 8 weeks. Drugs were administered 5 days per week at the following doses: RIF,
10 mg/kg; EMB, 100 mg/kg; PZA, 150 mg/kg; INH, 10 mg/kg |
