No. of mice to be sacrificed at the following time points  
Day  -13 Day 0 Wk 2 Wk 4 Wk 6 Wk 8 Total
Control Regimens  
Untreated 5 5 5       15
RPT+INH+EMB     5 5 5 5 20
RPT+MXF+EMB     5 5 5 5 20
RPT+EMB     5 5 5 5 20
Test Regimen  
RPT+INH+EMB+PZA     5 5 5 5 20
RPT+MXF+EMB+PZA     5 5 5 5 20
RPT+EMB+PZA     5 5 5 5 20
Total Mice 5 5 30 30 30 30 135
Treatment was initiated two weeks after infection at Day 0 and was administered for 8 weeks. Five untreated mice were kept after Week 2 for mortality assessment. The same scheme was used for 140 BALB/c and 140 nude mice
Table 5: Scheme for experiment 3: assessment of PZA activity in M. tuberculosis infected BALB/c and nude mice treated with RPT instead of RIF.