| |
No. of mice to be sacrificed at the following time points |
|
| Day -13 |
Day 0 |
Wk 2 |
Wk 4 |
Wk 6 |
Wk 8 |
Total |
| Control Regimens |
|
| Untreated |
5 |
5 |
5 |
|
|
|
15 |
| RPT+INH+EMB |
|
|
5 |
5 |
5 |
5 |
20 |
| RPT+MXF+EMB |
|
|
5 |
5 |
5 |
5 |
20 |
| RPT+EMB |
|
|
5 |
5 |
5 |
5 |
20 |
| Test Regimen |
|
| RPT+INH+EMB+PZA |
|
|
5 |
5 |
5 |
5 |
20 |
| RPT+MXF+EMB+PZA |
|
|
5 |
5 |
5 |
5 |
20 |
| RPT+EMB+PZA |
|
|
5 |
5 |
5 |
5 |
20 |
| Total Mice |
5 |
5 |
30 |
30 |
30 |
30 |
135 |
Treatment was initiated two weeks after infection at Day 0 and was administered
for 8 weeks. Five untreated mice were kept after Week 2 for mortality assessment.
The same scheme was used for 140 BALB/c and 140 nude mice |
