| |
Mouse strain |
Mean (SD) log10 CFU counts in mouse lungs at the following time points |
| |
Day -13 |
Day 0 |
Wk 2 |
Wk 4 |
Wk 6 |
Wk 8 |
| Control Regimens |
|
| Untreated |
BALB/c |
3.16 (0.16) |
6.40 (0.25) |
8.38 (0.69) |
|
|
|
| |
Nude |
3.35 (0.21) |
6.36 (0.20) |
8.61 (0.39) |
|
|
|
| RPT+INH+EMB |
BALB/c |
|
|
5.32 (0.25) |
4.06 (0.14) |
3.05 (0.31) |
1.10 (0.08) |
| |
Nude |
|
|
5.78 (0.13) |
4.90 (0.63) |
3.84 (0.10) |
3.08 (0.35) |
| RPT+MXF+EMB |
BALB/c |
|
|
5.18 (0.21) |
4.16 (0.11) |
3.57 (0.16) |
2.02 (0.17) |
| |
Nude |
|
|
5.70 (0.43) |
4.53 (0.45) |
3.91 (0.30) |
2.77 (0.55) |
| RPT+EMB |
BALB/c |
|
|
5.22 (0.22) |
4.26 (0.20) |
3.79 (0.14) |
1.90 (0.22) |
| |
Nude |
|
|
5.95 (0.28) |
4.89 (0.20) |
3.96 (0.04) |
3.00 (0.28) |
| Test Regimens |
|
| RPT+INH+EMB+PZA |
BALB/c |
|
|
5.22 (0.35) |
3.48 (0.30) |
2.85 (0.22) |
0.43 (0.50) |
| |
Nude |
|
|
5.72 (0.28) |
4.63 (0.35) |
3.60 (0.44) |
2.55 (0.40) |
| RPT+MXF+EMB+PZA |
BALB/c |
|
|
3.93 (0.52) |
2.75 (0.10) |
1.17 (0.50) |
0 |
| |
Nude |
|
|
5.23 (0.24) |
3.90 (0.32) |
3.67 (0.33) |
0.98 (0.39) |
| RPT+EMB+PZA |
BALB/c |
|
|
4.48 (0.21) |
2.85 (0.15) |
1.58 (0..35) |
0 |
| |
Nude |
|
|
5.45 (0.37) |
4.13 (0.28) |
3.73 (0.22) |
1.95 (0.39) |
Treatment was initiated two weeks after infection at Day 0 and was administered for
8 weeks. Drugs were administered 5 days per week at the following doses: RPT, 10
mg/kg; INH, 10 mg/kg; EMB, 100 mg/kg; MXF, 100 mg/kg; PZA, 150 mg/kg |
