Mouse strain Mean (SD) log10 CFU counts in mouse lungs at the following time points
  Day¬† -13 Day 0 Wk 2 Wk 4 Wk 6 Wk 8
Control Regimens  
Untreated BALB/c 3.16 (0.16) 6.40 (0.25) 8.38 (0.69)      
  Nude 3.35 (0.21) 6.36 (0.20) 8.61 (0.39)      
RPT+INH+EMB BALB/c     5.32 (0.25) 4.06 (0.14) 3.05 (0.31) 1.10 (0.08)
  Nude     5.78 (0.13) 4.90 (0.63) 3.84 (0.10) 3.08 (0.35)
RPT+MXF+EMB BALB/c     5.18 (0.21) 4.16 (0.11) 3.57 (0.16) 2.02 (0.17)
  Nude     5.70 (0.43) 4.53 (0.45) 3.91 (0.30) 2.77 (0.55)
RPT+EMB BALB/c     5.22 (0.22) 4.26 (0.20) 3.79 (0.14) 1.90 (0.22)
  Nude     5.95 (0.28) 4.89 (0.20) 3.96 (0.04) 3.00 (0.28)
Test Regimens  
RPT+INH+EMB+PZA BALB/c     5.22 (0.35) 3.48 (0.30) 2.85 (0.22) 0.43 (0.50)
  Nude     5.72 (0.28) 4.63 (0.35) 3.60 (0.44) 2.55 (0.40)
RPT+MXF+EMB+PZA BALB/c     3.93 (0.52) 2.75 (0.10) 1.17 (0.50) 0
  Nude     5.23 (0.24) 3.90 (0.32) 3.67 (0.33) 0.98 (0.39)
RPT+EMB+PZA BALB/c     4.48 (0.21) 2.85 (0.15) 1.58 (0..35) 0
  Nude     5.45 (0.37) 4.13 (0.28) 3.73 (0.22) 1.95 (0.39)
Treatment was initiated two weeks after infection at Day 0 and was administered for 8 weeks. Drugs were administered 5 days per week at the following doses: RPT, 10 mg/kg; INH, 10 mg/kg; EMB, 100 mg/kg; MXF, 100 mg/kg; PZA, 150 mg/kg
Table 6: Lung CFU counts in M. tuberculosis-infected BALB/c and nude mice treated with RPT-containing regimens with or without PZA (Experiment 3).