Codon Nucleotide change Aminoacid change Mutation type
512 AGC-TGC Ser-Cys Substitution
514 TTC-TTT Phe-Phe Silent
516 GAC-GTC Asp-Val Substitution
GAC-GGAC Asp- Insertion
GAC-TAC Asp-Tyr Substitution
GAC-GAG Asp-Glu Substitution
517 CAG-DEL Gln- Deletion
CAG-CAA Gln-Gln Silent
CAG-CCAG Gln- Insertion
518 AAC-AA_ Asn- Deletion
AAC-AAAC Asn- Insertion
AAC-GAC Asn-Asp substitution
519 AAC-ACC Asn-Thr Substitution
520 CCG-CCCG Pro- Insertion
524 TTG-ATG Leu-met Substitution
526 CAC-TGC His-Cys substitution
CAC-TAC His-Tyr substitution
CAC-CTT His-Leu substitution
CAC-CTC His-Leu substitution
CAC-GAC His-Asp substitution
CAC-CGC His-Arg substitution
CAC-ACC His-Thr substitution
531 TCG-TTG Ser-Leu substitution
TCG-TGG Ser-Trp substitution
Table 2: Pattern of mutations in RRDR region of rpoB gene in 35 RIFr M. tuberculosis strains