| |
Mean ± SD Number of Positive/Total (%) |
All ORD Number of Negative/Total (%) |
P value |
AUC |
| |
TB |
ORD TST+ |
ORD TST- |
|
|
| IgA |
|
| MPT64 |
0.848 ± 0.202a,b |
0.548 ± 0.240a |
0.388 ± 0.123b |
21/22 (95.5) |
0.0003 |
0.894 |
| |
2/12 (16.7) |
1/14 (7.1) |
0/8 () |
| MT10.3 |
0.809 ± 0.305 |
0.601 ± 0.198 |
0.586 ± 0.200 |
0.1416 |
0.706 |
| |
5/12 (41.7) |
1/14 (7.1) |
0/8 (0) |
| F1 |
0.468 ± 0.104a,b |
0.261 ± 0.125a |
0.225 ± 0.137b |
0.0007 |
0.894 |
| |
7/12 (58.3) |
0/14 (0) |
1/8 (12.5) |
| F2 |
0.786 ± 0.108a,b |
0.474 ± 0.205a |
0.479 ± 0.191b |
0.0008 |
0.92 |
| |
8/12 (66.7) |
1/14 (7.1) |
0/8 (0) |
| IgG |
|
| MPT64 |
0.461 ± 0.223 |
0.427 ± 0.171 |
0.385 ± 0.245 |
91.7 |
0.472 |
0.607 |
| |
(4/14, 28.6) |
(1/16, 6.25) |
(1/8, 12.5) |
| MT10.3 |
0.497 ± 0.274a |
0.400 ± 0.197b |
0.241 ± 0.142a,b |
91.7 |
0.004 |
0.71 |
| |
(3/14, 21.4) |
(2/16, 12.5) |
(0/8, 0) |
| F1 |
0.952 ± 0.181a |
0.753 ± 0.260a,b |
0.523 ± 0.286a,b |
87.5 |
0.002 |
0.801 |
| |
(8/14, 57.1) |
(2/16, 12.5) |
(1/8, 12.5) |
| F2 |
0.513 ± 0.188a |
0.460 ± 0.179b |
0.350 ± 0.113a,b |
91.7 |
0.061 |
0.664 |
| |
(5/14, 35.7) |
(2/16, 12.5) |
(0/8, 0) |
| IgM |
|
| MPT64 |
0.451 ± 0.179 |
0.336 ± 0.183 |
0.335 ± 0.205 |
95.2 |
0.266 |
0.648 |
| |
(3/10, 30%) |
(0/14, 0%) |
(1/7, 14.3%) |
| MT10.3 |
0.474 ± 0.207 |
0.349 ± 0,151 |
0.332 ± 0.223 |
95.2 |
0.212 |
0.667 |
| |
(3/10, 30%) |
(0/14, 0%) |
(1/7, 14.3%) |
| F2 |
0.422 ± 0.228a |
0.306 ± 0.302 |
0.247 ± 0.331a |
91 |
0.043 |
0.814 |
| |
(5/10, 50%) |
(2/14, 14.3%) |
(0/7, 0%) |
|
| Table 3: Differential levels in immune response by ELISA IgA, IgG and IgM to the new antigens F1 and F2, as well as MPT-64 and MT10.3, in serum samples from tuberculosis patients (TB) and controls with others respiratory diseases (ORD). SD: Standard Deviation; TST + or - : Tuberculin Skin Test Positive or Negative; AUC: Area Under Curve; a,b,cp<0.05) between groups tested (Mann Whitney test). |
