Compound

Average inhibition (%)

GI50a (µ M)

3a

22

20

3b

32

28

5

20

-

6

24

10.2

7

95

-

9

68

26

12

42

-

14

80

24

17a

88

12.2

17b

56

30

19a

86

-

19b

55

10.6

21

98

24

22

58

8.2

Positive controlb

95

 

Negative controlc

0

 

aGI50 = concentration for 50% growth inhibition
bAmphotericin B (1μ M)
cCulture medium and DMSO
Table 2: Anti-leishmanial activity of compounds 3a-9d at 50 mM against L. donovani axenic amastigotes.