compound Inhibition % of edema   Volume of edema (ml)b and %AIc
1 h 2 h 3 h 4 h
ref 0.33c ± 0.12 2.18de ± 0.45 2.30d ± 0.96 2.60e ± 2.21
Indomethacin 0.34 ± 0.02** (31)c 0.38 ± 0.07** (59) 0.42 ± 0.09** (65) 0.48 ± 0.05** (79)
 3 4.72c ± 0.08>**
(30)c
21.86c ± 0.86**
(45)c
33.69c ± 1.24**
(57)c
47.73c ± 2.21**
(63)c
 4 1.25d ± 0.03**
(33)c
15.28bc ± 1.02**
(42)c
21.01e ± 0.75**
(55)c
38.26 e ± 0.93**
(62)c
 5 6.27c ± 0.21**
(35)c
16.64b ± 1.55**
(48)c
26.07d ± 1.04**
(56)c
42.24d ± 1.08**
(61)c
 6 5.47a ± 3.25**
(39)c
13.63a ± 3.57**
(56)c
18.26a ± 4.52**
(54)c
43.05a ± 3.67**
(77)c
 8a 9.15b ± 2.42**
(32)c
11.15a ± 4.25**
(51)c
24.78b ± 2.65**
(65)c
36.24a ± 4.22**
(78)c
 8b 3.32e ± 0.01**
(31)c
12.58e ± 0.22**
(59)c
25.87e ± 0.88**
(63)c
35.71e ± 1.35**
(78)c
 8c 2.37e ± 0.01**
(25)c
13.01d ± 0.85**
(50)c
26.50d ±1.24**
(62)c
36.32b ± 2.52**
(78)c
 8d 2.15b ± 2.42**
(33)c
13.15a ± 4.25**
(51)c
25.78b ± 2.65**
(69)c
37.24a ± 4.22**
(78)c
LSD at 5% 5.50 4.12 4.53 3.58
aDose levels: test compounds (50 mg/kg body wt.), indomethacin (10 mg/kg body wt.)
bValues are expressed as mean ± SEM and analyzed by ANOVA
cValues in parentheses (percentage anti-inflammatory activity, AI%)
*Significantly different compared to respective control values, P<0.05
**Significantly different compared to respective control values, P<0.01
Table 1: Inhibitory effect in vivo anti-inflammatory activity of compounds 3, 4, 5, 6, 8 and Indomethacin on carrageenan- induced edema of the hind paw in rats.