Figure 2: Computed tomography of distal femurs and proximal tibiae (A) of rabbits that received intra-venous and intra-medullar infusion of autologous mesenchymal stem cells (MSC). Uninjected contralateral limbs served as the untreated or intravenous treated limbs (Fig 1A, 1B, and 1D). There were no significant changes on bone volume, bone mineral density, or drill hole filling in all regions of the femurs and tibiae (B). Histomorphometric evaluation of the distal femurs and proximal tibiae (C) showed no significant changes on cortical bone porosity, cortical bone thickness, or trabecular bone area in all regions of the femurs and tibiae (D).