Baseline 3 Months 6 Months 1 Year P Value KOOS             ADL Score (SD) 53.0 (37.7) 74.7 (36.5) 77.9 (37.9) 94.4 (18.8)     Change (95% CI)   21.7 (8.2 to 35.2) 3.2 (-12.0 to 18.2) 16.5 (-0.6 to 33.6) P<0.001 Pain Score (SD) 58.0 (29.1) 85.2 (12.6) 87.0 (12.8) 91.1 (7.4) P<0.001   Change (95% CI)   27.1 (13.7 to 40.7) 1.8 (-3.7 to 7.2) 4.1 (-0.6 to 8.8)   QOL Score (SD) 20.1 (18.3) 48.0 (28.8) 50.5 (29.3) 71.7 (21.1) P<0.001   Change (95% CI)   27.9 (19.6 to 36.2) 2.5 (-10.6 to 15.5) 21.2 (6.7 to 35.7)   Sport Score (SD) 21.3 (22.7) 52.7 (28.8) 59.1 (36.1) 80.4 (21.8) P<0.001   Change (95% CI)   31.4 (20.2 to 42.6) 6.4 (-8.8 to 21.7) 21.3 (5.0 to 37.5)   Symptoms Score (SD) 38.8 (30.0) 63.8 (35.2) 67.5 (35.9) 85.7 (12.8) P<0.001   Change (95% CI)   25 (12.6 to 37.4) 3.7 (-10.9 to 18.3) 18.3 (3.2 to 33.3)   WOMAC             Pain Score (SD) 57.0 (38.9) 75.2 (37.1) 76.6 (37.7) 92.5 (18.8)     Change (95% CI)   18.2 (5.4 to 31.0) 1.4 (-13.8 to 16.7) 15.9 (-1.3 to 34.1) P<0.001 Stiffness Score (SD) 44.6 (35.4) 66.5 (34.9) 71.0 (36.7) 85.7 (21.2) P=0.001   Change (95% CI)   21.9 (8.2 to 35.6) 4.5 (-10.4 to 19.3) 14.7 (-2.8 to 32.3)   Function Score (SD) 53.1 (38.4) 73.9 (36.9) 77.4 (38.5) 94.3 (19.1) P<0.001   Change (95% CI)   20.9 (6.9 to 34.8) 3.5 (-12.2 to 19.1) 16.9 (-0.8 to 34.7)

Table 1: KOOS and WOMAC domain scores at baseline, 3 months, 6 months and 1 year. P-value represents repeated measures ANOVA test for within subject variation over the time periods. The change represents the mean difference (95% confidence interval) between each time point. Significant differences are highlighted in bold type (p<0.05).