Formula code
Zero order
First order
Higuchi
Korsmeyer-Peppas
% burst release after 1 hour ± SD
T50%
(h)
r
k0
r
k1
r
kH
r
n
F1
0.920
11.795
-0.890
-0.302
0.944
39.155
0.989
0.491
40 ± 1.43
2.5
F2
0.994
9.721
-0.991
-0.083
0.983
29.925
0.993
0.803
17 ± 2.76
4.5
F3
0.982
10.385
-0.984
-0.111
0.992
32.616
0.990
0.593
25 ± 2.80
3.5
F4
0.972
10.440
-0.983
-0.130
0.994
33.238
0.982
0.508
31 ± 3.62
3.0
F5
0.969
10.748
-0.904
-0.188
0.993
34.179
0.979
0.455
37 ± 1.78
3.0
F6
0.988
6.405
-0.984
-0.040
0.964
19.377
0.989
0.673
12 ± 3.82
3.5
F7
0.988
11.368
-0.986
-0.118
0.982
35.116
0.997
0.797
18 ± 2.98
7.0
F8
0.977
10.841
-0.984
-0.131
0.994
34.299
0.996
0.582
29 ± 3.89
3.0
F9
0.962
11.769
-0.934
-0.200
0.992
37.796
0.985
0.502
36 ± 4.20
2.5
Pure GLZ
0.989
13.439
-0.947
-0.165
0.944
39.858
0.982
1.052
-
4.0
Table 3:
Correlation coefficient and T
50%
, calculated from the release data of GLZ-loaded Polycaprolactone microparticles after fitting the whole release profile of GLZ from various microparticles into different mathematical models (n=3).
