Obafemi Awolowo University
Title: Antioxidants status of stz-induced diabetic rats treated with extract of momordica charantia
O A Komolafe has received her PhD in Anatomy at Obafemi Awolowo University, Ile -Ife Osun State, Nigeria in May 2012. Currently, she is a senior lecturer, working as a postdoctoral scholar in the Discipline of Clinical Anatomy, Laboratory of Medicine & Medical Sciences, College of Health Sciences, Nelson Mandela School of Medicine, University of Kwazulu-Natal, Durban, South Africa. She has successfully completed her Administrative responsibilities as Departmental coordinator for Year 3 Medical & Dental students 2011-2014 and Chairman, Departmental welfare committee. Her research has included Diabetes mellitus, Cardiovascular, Electron microscopy, Histology & Histochemistry, Immunohistochemistry and Pre-eclampsia. Based on this research and fellowship training, she has received several awards and honors, such as: Carnegie New York for female academic staff 2011, TET funding Awards 2012 and Postdoctoral scholarship 2013. She has authored a reasonable number of research articles in reputable international journals to her credit. She is a member of Placental Research Group South Africa, Anatomical Society of Nigeria, Diabetes Research OAU.
The present study investigated the effects of M. charantia on hyperglycaemia and selected markers of antioxidants activities (which include thiobarbituric acid reactants (TBARS), Catalase, Glutathione, Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx) in streptozotocin-induced diabetic Wistar rats and compared the effects with those of glimepiride, an oral blood-glucose-lowering drug of the sulfonylurea class. Forty healthy adult Wistar rats of both sexes were randomly assigned into five groups A, B, C, D and E of eight rats each. Group A were the control (normal rats); B were the experimentally-induced diabetic rats; C were diabetic rats treated with methanolic extracts of M. charantia for two weeks; D were diabetic rats treated with methanolic extracts of M. charantia for four weeks. E was diabetic rats treated glimepiride for four weeks. Results showed that extract have potent hypoglycaemic effects in diabetic rats and suggested that M. charantia could restore to within normal levels, the observed changes in antioxidants markers of diabetic rats and in more potent effect than glimepiride.