Tel-Aviv University, Israel
Title: ASIA - Autoimmune (Auto-inflammatory) syndromes induced by adjuvants
Yehuda Shoenfeld is the founder and head of the Zabludowicz Center for Autoimmune Diseases, at the Sheba Medical Center which is affiliated to the Sackler Faculty of Medicine in Tel-Aviv University, in Israel. Dr. Shoenfeld is the Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases at the Tel-Aviv University.rnHis clinical and scientific works focus on autoimmune and rheumatic diseases, and he has published more than 1700 papers in journals such as New Eng J Med, Nature, Lancet, Proc Nat Acad Scie, J Clin Invest, J Immunol, Blood, FASEB, J Exp Med, Circulation, Cancer and others. His articles have had over 31,000 citations. He has written more than three hundred and fifty chapters in books, and has authored and edited 25 books, some of which became cornerstones in science and clinical practice, such as "The Mosaic of Autoimmunity", "Infections and Autoimmunity" and the textbook "Autoantibodies" and "Diagnostic criteria of autoimmune diseases", all of which were published by Elsevier and sold by the thousands.rnrnHe is on the editorial board of 43 journals in the field of rheumatology and autoimmunity and is the founder and the editor of the IMAJ (Israel Medical Association Journal) the representative journal of science and medicine in the English language in Israel, and also is the founder and Editor of the "Autoimmunity Reviews" (Elsevier) (Impact factor 6.6) and Co-Editor of "Journal of Autoimmunity" (Impact factor 7.4). For the last twenty years Dr. Shoenfeld has been the Editor of "Harefuah" The Israel journal in medicine (Hebrew) and he has edited the Israel Medical Encyclopedia (10 volumes, 5000 items). He had organized over 20 international congresses in autoimmunity. He is the editor-in-chief for Journal of Autoimmunity along with M. Eric Gershwin (University of California, Davis). According to the Journal Citation Reports, the journal has a 2012 impact factor of 8.145, ranking it 11th out of 137 journals in the category "Immunology”. This journal is a peer-reviewed medical journal covering research on all aspects of autoimmunity. It was established in 1988 and is published 8 times per year by Elsevier.rn
Four enigmatic medical conditions were described recently, all characterized by hyperactive immune response and similarrnclinical and laboratory manifestations. Th ese conditions (siliconosis, Gulf War Syndrome, macrophagic myofasciitisrnsyndrome and post-vaccination phenomena) imply that environmental factors may play a role in inducing or aggravatingrnautoimmunity and auto-infl ammation. In rare occasions vaccines may induce autoimmune or auto-infl ammatory conditionsrnboth in animals and in humans. Th ese conditions - defi ned diseases (Gullian-Barre syndrome) or enigmatic ones - havernbeen reported following vaccines and vaccination protocols. Th e susceptibility factors and the temporal association betweenrnvaccines and these immune mediated reactions remain to be defi ned; however, the similarities between vaccines and infectionsrnand the addition of adjuvants to almost every vaccine are considered major contributors to such adverse events. In MMF arncause was clearly delineated. MMF is a rare condition caused by deposition of alum, an adjuvant in diff erent vaccines, whichrncause an immune mediated muscles disease. In genetically prone patients, alum may induce this syndrome. Another similarrnphenomenon is exposure to silicones. In a study, a group of patients with silicone breast implants had a statistically signifi cantrnincrease in 16 of 28 investigated symptoms consistent with fi bromyalgia and chronic fatigue syndrome criteria, comparedrnto a group of women who underwent reduction mammoplasties, congruent with the FDA’s establishment of a link betweenrnfi bromyalgia and ruptured silicone implants. A common denominator to these syndromes is the trigger entailing adjuvantrnactivity. We suggest including these four conditions in one syndrome, the "Autoimmune Syndrome Induced by adjuvants" (ASIA).