M J Zibaeenezhad

M J Zibaeenezhad

Shiraz Medical University, Iran

Title: Beta-Thalassemia and coronary artery disease


Mohammad Javad Zibaeenezhad is at present professor of cardiovascular research center, shiraz university of medical sciences, shiraz, Iran


B-thalassemia belongs to the group of hemoglobinopathies, which is the most common monogenic disorder in the world population. Homozygous B-thalassemia is the most sever presentation of the disease. It is estimated that there are at least 20000 individuals with this disorder in Iran; and despite tight screening control, around 400 aff ected infants are still born annually, which is a major burden on our health system. Minor Beta-thalassemia is a disorder without any special symptoms, which only causes mild anemia. In thalassemia patients, accelerated erythropoiesis and enhanced cholesterol consumption have been suggested as a dominant mechanism of low level of lipoprotein. Hyperlipidemia is a risk factor for cardiovascular disease, although low level of serum lipids can act as a protective factor. Several studies show low incidence of myocardial infarction and coronary artery disease in Beta-thalassemia patients.

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