Universidade Monte Serrat, Brazil
Title: Effect of a grape phenolic concentrate on plasma cholesterol levels in humans
Rogerio Correa Peres has completed his Ph.D. at the age of 30 years from Universidade Federal de Sao Paulo-UNIFESP and he is finishing his postdoctoral studies from Universidade Federal de Sao Paulo-UNIFESP. He is the Physiology Professor of Universidade Monte Serrat-UNIMONTE and Catholic University of Santos-UNISANTOS. He has published 5 papers in reputed journals and 1 book chapter, and is serving as reviewer for more than 6 journals.
Several studies pointed atherosclerosis as the main cardiovascular disease, the leading cause of morbidity and mortality among adults in Western countries. There are a lot of studies has pointed that grape compounds as red wine or grape concentrate, rich in polyphenols, has possible antioxidant effect leading to decrease of cellular events of atherosclerosis and reduction of cardiovascular risks. This paper proposes an investigation of the effects of a 28 days diet of 70 mg daily of a grape juice concentrate rich in anthocyanidins, the G8000, on total cholesterol and its fractions, LDL, VLDL and HDL, and triglycerides, and in plasma enzymes biomarkers of muscle injury, CK, CK-MB and LDH in normal human subjects. The results showed decreased levels of plasma LDL measures, and increased levels of HDL. There are no differences for the other lipid measures. As regard the enzyme measures we observed decrease of CK_MB and increase of LDH measures, what suggest the antioxidant effect of the G8000. The results suggest that the G8000 can be considered as a tool to decrease cardiovascular diseases risks.