Djillali Liabes University
Title: Effect of gender and body weight on postprandial glucose and lipid metabolism in adults with type 2 diabetes
I am Méghit Boumédiène KHALED, Professor at Djillali Liabes University, Faculty of Natural and Life Sciences, Sidi-Bel-Abbes, Algeria. I have been teaching at this university for over 13 years; first as an assistant while doing a Ph.D. degree in Health & Environment; then as an assistant professor between 2001-2008. Later, in 2009 as Associate Professor, and this year I have been named full Professor with distinction. I have taught Nutrition, Biochemistry, Enzymology, Enzymes in Biotechnology, Purification of proteins, Food Biochemistry, Analysis Techniques in Biology, EAP (English for Academic Purposes), and Methodology of Research at all university levels, from freshman to graduate (doctoral) levels. I have also supervised about fifteen Masters’ degree students, and actually, ten (10) PhD students are under my supervision. In parallel, I have for the past five years or more, been seriously interested and involved in teaching EAP for Biology students. For this aim, I first obtained a degree of "license" in English and currently doing a Master (MA) in "Language Didactic". My primary research interests are: the study of the effect of fasting during the holy month of Ramadan on patients with type 2 diabetes. I've been researching in this area for over 10 years. I am interested in research methods; epidemiology and biostatistics; health of adolescents groups; and promoting the use of routine data collections for research purposes. Furthermore, I am giving, for physicians and health care providers (HCP) throughout the country, sponsored by ACON Laboratory, Inc (USA), conferences on the management of type 2 diabetes during Ramadan fasting month, the risks of obesity and overweight.
Background: Massive health problem is caused by the increasing worldwide prevalence of type 2 diabetes in both developed and developing countries. The magnitude of the healthcare problem of type 2 diabetes is the result of the disease itself and its association with several risk factors for cardiovascular diseases such as obesity and postprandial dyslipidemia.
Objective and Methods: This study took place in two cities from the northwestern region of Algeria (Sidi-Bel-Abbes and Mascara). The main goal was to assess the effect of body weight and gender difference on postprandial lipid and glucose responses in type 2 diabetes patients. Ninety-three adult patients with type 2 diabetes aged 55.65 (13.81) years were studied. Weight, height, waist circumference and body mass index (BMI) were measured. Fasting and postprandial glucose and lipid (total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, apo A-I and apo B) profiles were evaluated.
Results: Our results indicated a positive correlation between postprandial glucose and BMI in women (r2 = 0.041). Negative correlation with BMI was noticed for PP TG in both males (r2 = 0.011) and females (r2 = 0.021). A significant difference (p = 0.019) was observed for PP HDL-c in women 0.39 (0.10) g/L vs. men 0.33 (0.12) g/L and for PP apo A-I (women: 1.33 (0.27) g/L vs. men: 1.09 (0.34) g/L; p = 0.0003). According to gender and weight groups (normal weight, overweight and obese), our results indicated that female gender and overweight are associated with elevated PP HDL-c and PP apo A-I levels. However, obesity in women is related to high concentration of PP TG.
Conclusion: Results of the present study suggest that gender difference and weight classes are important factors that contribute to determining the postprandial responses, both for glucose and lipids, in type 2 diabetic patients.