Eulji University School of Health Science, South Korea
Title: Effects of fasting glucose levels on the association between CDH13 (rs4783244) and adiponectin among Korean population
Dr. Jae Woong Sull (MHS, Ph.D.) is an Assistant Professor at Eulji University. He obtained both his Ph.D. degree in the Genetic Epidemiology and Master of Health Science degree in Epidemiology from Yonsei University in Korea. He was also trained as a postdoctoral fellow in genetic epidemiology at Johns Hopkins Univiersity in USA. He has published over 50 papers in peer-reviewed journals.
Adiponectin is associated with obesity and insulin resistance. Several genome-wide association studies of adiponectin levels have identified candidate genes, including the CDH13 gene. The study objective was to examine the association of serum adiponectin levels (or hypoadiponectinemia) with SNP rs4783244 in CDH13 gene considering fasting blood glucose levels. This study included 2,005 subjects. Hypoadiponectinemia was defined as the lowest quartile of adiponectin. The CDH13 gene SNPs were genotyped via the TaqMan reaction. The multivariate linear regression models and multiple logistic regression analysis were performed. The majority of individuals were middle-aged. Subjects with the GG genotype had a 2.44-fold (range 1.97–3.03-fold) higher risk of hypoadiponectinemia than subjects with the TG/TT genotype. When analyzed by fasting blood glucose levels, the CDH13 association was much stronger in male subjects with pre-diabetes (odds ratio, 10.96; 95% confidence interval, 4.31–27.88; P < 0.0001). Our results suggested that the association between CDH13 and adiponectin can be modified by fasting blood glucose levels.