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Yasmine Amr Issa

Yasmine Amr Issa

Alexandria University
Egypt

Title: Evaluation of serum level of B lymphocyte activating factor of the tumour necrosis factor family and peripheral blood CD19+ B lymphocytes in patients with generalized vitiligo

Biography

Yasmine Issa has completed her MBSCh at the age of 24 from Alexandria Faculty of Medicine, then completed her MD and PHD. In 2008-2009, Yasmine was a research fellow in Leipzig University Clinic of Dermatology, Allergology and Venerology. Currently, she is a lecturer in Medical Biochemistry and Molecular Biology department, Alexandria Faculty of Medicine , where she resumes her postdoctoral studies. She is a researcher in nanomedicine lab, genomics center , and Egybiotech, a leading research incubator in Egypt. She is a reviewer in the journal “Andrologia”. She has publications and posters in the field of andrology, cardiovascular diseases,and nanomedicine.

Abstract

Background: There is a strong body of evidence supporting an autoimmune basis forgeneralized vitiligo. B lymphocyte activating factor of the tumour necrosis factor family (BAFF)is known to be involved in the pathogenesis and progression of autoimmune diseases. Objective: To evaluate serum levels of BAFF and peripheral blood CD19+ Blymphocytes in patients with generalized vitiligo and to explore the effect of treatment withnarrow band ultraviolet B (NB-UVB) on their levels. Methods: Serum BAFF and peripheral blood CD19+ B lymphocytes were measured in30 patients with generalized vitiligo and 30 healthy control subjects. Patients received NB-UVBsessions for three months and follow up samples were then collected. Results: Serum BAFF and peripheral blood CD19+ B lymphocytes were significantlyhigher in patients than in control subjects (p<0.001). No significant correlation was detectedbetween serum BAFF and CD19+ B lymphocytes. In addition, correlations between serumBAFF or CD19+ B lymphocytes and disease duration, activity and severity were nonsignificant. After treatment with NB-UVB, significant reduction in the vitiligo area severity index (VASI)score was detected (p=0.02), but serum BAFF levels and Peripheral blood CD19+ Blymphocytes did not show significant change. Conclusion: Elevation in serum BAFF levels and CD19+ B lymphocytes in generalized vitiligo patients possibly provides further support to the autoimmune hypothesis of the disease and to the possible role played by B lymphocytes in the pathogenesis of the disease