Liaquat University of Medical & Health Sciences
Title: Fuel metabolism in diabetic pregnancy
Firdous Mumtaz worked as professor in Public University LUMHS of Pakistan and had 24 Publications in various national and International Journals. He was keenly interested in gestational diabetes and their consequences in pregnancy and labor leads to undiagnosed miscarriages and still birth in third world countries.
The effect of diabetic pregnancy on fuel metabolism is one of the underutilization of exogenous fuel and one production from endogenous source in the fasted state, result in impaired glucose tolerance (IGT) in some women which lack necessary B- Cell reserve to maintain Euglycaemia during pregnancy and have significantly lower insulin response as compared to glucose tolerant control in 1st and 2nd trimester of pregnancy. The response of C- peptide is reduce to oral glucagon and level of serum pro insulin concentrations are increased resulting for insulin treatment along with abnormalities of glycerol and nonestified fatty acids metabolism impaired lipolysis. All this leads to decrease B- Cell function and increase in insulin requirement to maintain euglycaemic state. Pregnancy induced lipolysis, dyslipidaemia abnormal glucose tolerance test is also associated with elevated serum (GGT) Glutamyl transferase Enzyme. Classification of Diabetes in Pregnancy • Pregestational diabetes: pre-existing type 1 or type 2 or secondary. • Gestational diabetes: diagnosis is made post gestationally: normal glucose tolerance • Any type of diabetes mellitus occurring first in pregnancy. Consequences of Changes in Fuel Metabolism during Diabetic Pregnancy Increased hyperglycemia effects both Mother & fetus in all three trimester. 1st trimester: Congenital malformations, spontaneous abortion, Growth retardation. 2nd trimester: Hypertrophic Cardiomyopatus. 3rdtrimester: Hyperinsulinemia leads to Macrosomia, RDS, hypomagnesemia, hypoglycemia, hypocalcaemia, hypoglycemia, polycythemia, hyperbilirubinemia, stillbirth. Maternal Complications are Placental insufficiency, Pre eclampsia, Eclampsia, poly hydramnios. Long term impact of GDM on maternal health Increased risk of development of diabetes later on, obesity, and premature cardiovascular risk.