University of Kwazulu-Natal, South Africa
Title: Momodica charantia improves hyperglycemia and left ventricular histology of streptozotocin-induced diabetic wistar rats
Omobola Aderibigbe Komolafe has received her PhD in Anatomy at Obafemi Awolowo University, Ile -Ife Osun State, Nigeria during the period 30th May 2012. Currently, she is a senior lecturer, working as a postdoctoral scholar in the Discipline of Clinical Anatomy, Laboratory of Medicine & Medical Sciences, College of Health Sciences, Nelson Mandela School of Medicine, University of Kwazulu-Natal, Durban, South Africa. She has successfully completed her Administrative responsibilities as Departmental coordinator for Year 3 Medical &Dental students 2011-2014 and Chairman, Departmental welfare committee. Her research has included Diabetes mellitus, Cardiovascular, Electron microscopy, Histology &Histochemistry, Immunohistochemistry and Pre-eclampsia. Based on this research and fellowship training she has received several awards and honors, such as: Carnegie New York for female academic staff 2011,TET funding Awards 2012 and Postdoctoral scholarship 2013. She has authored a reasonable number of research articles in reputable international journals to her credit. She is a member of Placental Research Group South Africa, Anatomical Society of Nigeria, Diabetes Research OAU.
The present study examined the effects of Momordica charantia on symptoms of diabetes, hyperglycemia and histology of the heart of streptozotocin-induced diabetic rats. Forty healthy adult Wistar rats of both sexes, were randomly assigned into five groups A, B, C, D and E of eight rats each. Group A were the control (normal rats); B were the experimentally-induced diabetic rats; C were diabetic rats treated with methanolic extracts of M. charantia for two weeks (withdrawal group); D were diabetic rats treated with methanolic extracts of M. charantia for four weeks. E was diabetic rats treated glimepiride for four weeks. Physical changes, body weight and fasting blood glucose were monitored through the experimental period. Results showed a non significant difference (p>0.05) in the average body weight of C group when compared with the diabetic group. Groups D and E showed significant increase (p < 0.05) in the mean body weights when compared with the rats in groups A, B and C. Blood glucose of C increased significantly after two weeks of extract withdrawal, while D and E rats maintained normoglycemic levels. Histological studies revealed that M. charantia and glimperide restored the disorganized myofibrils of the left ventricle observed in diabetic rats. KEYWORDS: Diabetes, Momodica charantia, Hyperglycemia, Histology, Heart.