University General Hospital of Patras Greece
Title: Platelet reactivity during different stages of sepsis: Preliminary results
K.Akinosoglou is a medical doctor with a special interest in infectious diseases, currently undergoing specialty training in the field of internal medicine. She recently completed her PhD in malaria basic science research at Imperial College London and is now a post-doctoral research fellow at the Dept of Infectious Diseases, at the University Hospital of Patras. CA Gogos is Professor in Internal Medicine and Infectious Diseases, at the University Hospital of Patras. He is the author of more than 90 peer reviewed articles in PubMed and 130 in Google Scholar and is cited by more than 2100 articles in SCOPUS and 3200 in Google Scholar. He is reviewer in many Scientific Journals. He has a special interest on Medical Education and he chairs the Curriculum Committee of Patras University Medical School since 2006.
Introduction: Activation of blood platelets is a typical finding in patients with systemic inflammation and sepsis. Platelet adhesion to endothelium has been shown to enhance the pro-coagulatory activity of endothelial cells, impairing microcirculation thus, may lead to multiple organ dysfunction. However, the effects of bacterial products on platelet function have not been found to be consistent and may vary according to the species, the timing of the study, and the pathogenesis of sepsis. Aim of this study was to assess platelet reactivity during different stages of sepsis. Materials and Methods: Patients presenting to our department, exhibiting signs of inflammation due to an infectious agent were assorted to two distinct groups i.e. uncomplicated infection and sepsis, depending on whether they fulfilled diagnostic criteria for sepsis. Platelet reactivity was measured once using the point-of-care VerifyNow assay, in platelet reactivity units (PRU). Results: Preliminary results from twenty patients have shown a significant difference in platelet reactivity (p=0.01) between groups of uncomplicated infection and sepsis (182±17.2 vs 274±19.6 PRU respectively) Conclusion: Platelet reactivity is increased when sepsis is present in comparison to uncomplicated infection